Significant doses of acetaminophen might deplete the glutathione merchants to make sure that inactivation in the poisonous metabolite is reduced. At superior doses, the capability of metabolic pathways for conjugation with glucuronic acid and sulfuric acid may very well be exceeded, causing increased metabolism of acetaminophen by alternate pathway

Opioids can cross the placental barrier and possess the probable to lead to neonatal respiratory despair. Opioid use all through pregnancy may well result in a physically drug-dependent fetus. Right after delivery, the neonate may perhaps put up with critical withdrawal symptoms.This doc would not contain all doable Unwanted effects and Many others